DSP-6952 hydrobromide ( DSP6952;Minesapride )

产品货号. M10627 CAS No. 1184661-33-3

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Datasheet

HNMR

HPLC

MSDS

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产品名称

DSP-6952 hydrobromide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.
产品描述

DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c; enhances gastric motility and causes colonic giant migrating contractions (GMCs) associated with defecation in conscious dogs, having ED50 value for inducing GMCs of 1.56mg/kg; rapidly increases fecal wet weight without increasing fluid content in mice (1-10mg/kg, p.o.).
同义词

DSP6952;Minesapride
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

——
适应症

——

CAS Number

1184661-33-3
分子量

535.86
分子式

C21H32BrClN4O5
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(NC[C@H]1CN(CC2CCN(C(CO)=O)CC2)CCO1)C3=CC(Cl)=C(N)C=C3OC.[H]Br.[H]O[H].[H]O[H]
化学全称

(S)-4-amino-5-chloro-N-((4-((1-(2-hydroxyacetyl)piperidin-4-yl)methyl)morpholin-2-yl)methyl)-2-methoxybenzamide hydrobromide

1. Mine Y, et al. Eur J Pharmacol. 2018 Feb 9;826:123-132.
2. Tsubouchi T, et al. Eur J Pharmacol. 2018 Mar 1;826:96-105.

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